Author(s)

Guixiang Tian, Bo Zhang, Bo Lian, Xiaohui Qi, Zhiqin Gao, Jingliang Wu

Corresponding Author

Jingliang Wu

Abstract

Difunctional nano-micelle is prepared from hyaluronic acid modified with folic acid (FA-HA) and hyaluronic acid modified with histidine (His-HA). Doxorubicin (DOX) is selected as the drug to prepare drug loaded nano-micelle; the particle size and Zeta potential of nano-micelle are analyzed. The inhibition rate of nano-micelle on the growth of human hepatoma cells (HepG2) is detected by MTT method; the anti-tumor activity of nano-micelle is analyzed in vivo. The results show that drug loading mixed micelles are spherical with the particle size of 238.4-312.7 nm. The degree of dispersion is good, and the Zeta potential is -12.5~-9.8m V. The anti-tumor experiment in vitro and in vivo show that the drug loaded nano-micelle is more effective in anti-hepatoma than doxorubicin.

Keywords

Doxorubicin, Hyaluronic acid, Nano-micelle, Folic acid.